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Research​
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The Lee group has interests in advancing spatial metabolomics using mass spectrometry imaging (MSI) technology with matrix-assisted laser desorption ionization (MALDI). Most recent interests include on-tissue chemical derivation (OTCD) to improve analytical sensitivity and in vivo isotope labeling to trace metabolic activities in plant systems. We are also interested in its forensic applications to determine fingerprint age and develop a rapid antibiotic resistance susceptibility test.

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On-tissue chemical derivatization for untargeted spatial metabolomics
in vivo isotope labeling for mass spectrometry imaging
Deuterium labeling mass spectrometry for rapid antimicrobial susceptibility testing
Chemical Imaging of Latent Fingerprints
Mass Spectrometry Imaging of Plant Metabolites (inactive)
Bio-oil Analysis (inactive)
High-throughput MALDI Metabolomics (inactive)

Raw MS imaging data for most of our previous publications are now available at METASPACE (https://metaspace2020.eu/), MS imaging data repository and web-based metabolite annotation tool for high-mass resolution data at EMBL.

Follow the link: https://metaspace2020.eu/datasets?q=Iowa%20State

Please note that not all data are available as it requires <3ppm mass accuracy while our previous instrument has mass accuracy <5ppm. We tried our best to re-calibrate with a few known peaks in the dataset, which did not always result in success.

Most data are from maize root, leaf, stem, and seeds.

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