Lee Laboratory
for Biological Mass Spectrometry
Department of Chemistry
Iowa State University
2021-Present
115. Mapping Double-Bond Positional Isomers of Phosphatidylcholines in Zebrafish Using OzMALDI Mass Spectrometry Imaging, Shanika M. Weerasinghe, Josiah J. Rensner, Jeffrey J. Essner, Young Jin Lee, J. Am. Soc. Mass Spectrom. 2026, DOI: 10.1021/jasms.6c00145.
114. Beyond Identification: Inferring Physical Activity from Fingerprint Lipids Using Machine Learning, Daphne R. Patten, Raven L. Buckman Johnson, Trevor T. Forsman, and Young Jin Lee* Analytical Methods, 2026, 18, 3286-3293. DOI: 10.1039/D5AY02066B.
113. Advanced Tissue Imprinting with Pneumatic Press for Mass Spectrometry Imaging of Plant Tissues, Pubudu Nuwan Perera Hapuarachchige, Vy T. Tat, and Young Jin Lee, J. Mass Spectrometry. 2026, DOI: 10.1002/jms.70007
112. Anna Uhlmansiek, Josiah J. Rensner, and Young Jin Lee*, Improving Metabolite Annotations in On-Tissue Chemical Derivatization Mass Spectrometry Imaging by Functional Group Filtering and Hydrogen Deuterium Exchange, J. Am. Soc. Mass spectrom. DOI: 10.1021/jasms.5c00293.
111. Raven L. Buckman Johnson, Vy T. Tat, Young Jin Lee, Unsupervised Machine Learning for Mass Spectrometry Imaging Data Analysis with in vivo Isotope Labeling, Analyst, 2025, 150, 4404-4413 DOI: 10.1039/D5AN00649J.
110. Josiah J. Rensner, Hyojin Kim, Kiyoul Park, Edgar B. Cahoon, and Young Jin Lee*, OzMALDI: A Gas-Phase, In-Source Ozonolysis Reaction for Efficient Double-Bond Assignment in Mass Spectrometry Imaging with Matrix-Assisted Laser Desorption/Ionization, Anal. Chem. 2025, 97, 7447-7455. https://doi.org/10.1021/acs.analchem.5c00284
109. Tat, Vy; Lee, Young-Jin (2025). Mass spectrometry dataset of D2O and 13CO2 labeling experiments on Lemna minor. Iowa State University. Dataset. https://doi.org/10.25380/iastate.28540523.v1
108. Na, Sumin; Lee, Young-Jin (2024). Mass spectrometry data files in D2O isotope labeling experiments of Arabidopsis thaliana. Iowa State University. Dataset. https://doi.org/10.25380/iastate.26076799.v1
107. Targeted engineering of camelina and pennycress seeds for ultrahigh accumulation of acetyl-TAG, Linah Alkotami, Dexter J. White, Kathleen M. Schuler , Maliheh Esfahanian, Brice A. Jarvis , Andrew E. Paulson, Somnath Koley, Jinling Kang, Chaofu Lu, Doug K. Allene, Young- Jin Lee, John C. Sedbrook, and Timothy P. Durrett, Proc. Nat. Ac. Sci., 2024, 121 (47), e2412542121. https://www.pnas.org/doi/10.1073/pnas.2412542121
106. Visualizing 13C-labeled Metabolites in Maize Root Tips with Mass Spectrometry Imaging, Lee, Young Jin; Hapuarachchige, Pubudu; Larson, Evan; Le, Ngoc; Forsman, Trevor, J. Am. Soc. Mass Spectrom. 2024, 35, 7. https://doi.org/10.1021/jasms.4c00042
105. Mass Spectrometry Imaging of Arabidopsis thaliana with in vivo D2O Labeling, Sumin Na, Young Jin Lee*, Front. Plant Sci. 2024, 15:1379299, https://doi.org/10.3389/fpls.2024.1379299.
104. Spatiotemporal Study of Galactolipid Biosynthesis in Duckweed with Mass Spectrometry Imaging and in vivo Isotope Labeling, Vy T. Tat and Young Jin Lee, Plant and Cell Physiology, 2024; pcae032.https://doi.org/10.1093/pcp/pcae032
96. Efficient Hydrogen-Deuterium Exchange in MALDI-MS Imaging for Confident Metabolite Identification. Rensner, J. J.; Lee, Y. J.* Anal. Chem. 2022, 94,11129*11133.
95. Rapid and Automatic Annotation of Multiple On-Tissue Chemical Modifications in Imaging Mass Spectrometry with METASPACE, E. Larson, T.T. Forsman, L. Stuart, T. Alexandrov, Y.J. Lee*. Anal. Chem. 2022, 94(25), 8983-8991.
94. Rapid Antibiotic Susceptibility Testing by Deuterium Labeling of Bacterial Lipids in On-Target Microdroplet Cultures. Larson, E. A.; Rensner, J. J.; Larsen, K. R.; Bellaire, B.; Lee, Y. J.* J. Am. Soc. Mass Spectrom. 2022, 33(7), 1221-1228.
93. “Complex changes in membrane lipids associated with modification of autophagy in Arabidopsis”, Yosia Mugume, Geng Ding, Maria Emilia Dueñas, Meiling Liu, Young Jin Lee, Basil J. Nikolau, Diane C Bassham*, Metabolites, 2022, 12(2), 190.
